Thai researchers published a paper on kratom in the Songklanakarin Journal of Science and Technology. There are also library listings for this paper. They specifically study methanol extracts of mitragyna speciosa showing that the methanol extract of kratom and the alkaloidal extract of kratom both have analgesic effects in mice. They calculated the 50% lethal dose (LD50) of these extracts, which were 4.90 g/kg for the methanol extract and 173.20 mg/kg for the alkaloidal extract. They conclude that there are little or no behavioral effects caused by the mitragyna speciosa
This can function as a replication of the analgesic action of mitragyna speciosa, but I believe the action of mitragyna speciosa has already been replicated several times. I get the impression that these researchers made some mistakes with their alkaloidal extract, perhaps not having the right proportion of 7-hydroxymitragynine involved which compromises their results.
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An interesting paper indeed.
It seems they used both a hot plate and tail flick assay, and reported that kratom only seems to increase the pain threshold in the former, not the latter.
Perhaps this wasn't analgesic activity, but just a reduction in movement. The hot plate assay requires the animal to be active to show it's in pain, but the tail flick assay just requires the tail to be flicked away from a source of heat. It's interesting that the test which requires far less activity showed no effect.
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